The Hoareau Lab: Mitochondrial Injury and Shock Research
Led by Guillaume Hoareau, DVM, PhD, Associate Professor of Emergency Medicine and CVRTI Investigator, the Hoareau Lab studies mitochondrial pathobiology in critical illness, hemorrhagic shock, ischemia-reperfusion injury, trauma resuscitation, and cardiac arrest.
A Translational Shock Research Laboratory
Investigating Mitochondrial Injury in Shock and Critical Illness
The Hoareau Lab bridges emergency and critical care medicine with fundamental mechanisms of cellular injury and recovery. Our work centers on mitochondrial pathobiology as a unifying mechanism of organ injury in critical illness, using clinically relevant large-animal translational models.
About the Hoareau LabOur Research
The Hoareau Lab focuses on advancing our understanding of mitochondrial injury in critical illness, exploring mitochondrial-targeted therapies for hemorrhagic shock, ischemia-reperfusion injury, and trauma resuscitation through clinically relevant large-animal translational models.
Featured Publications
Recent publications highlight advances in mitochondrial injury, hemorrhagic shock, and ischemia-reperfusion research.
Elamipretide mitigates ischemia-reperfusion injury in a swine model of hemorrhagic shock. Sci Rep. 2023;13(1):4496.
Esmolol reduces myocardial injury induced by resuscitative endovascular balloon occlusion of the aorta (REBOA) in a porcine model of hemorrhagic shock. Injury. 2020;51(10):2165-2171.
Not ready for prime time: Intermittent versus partial resuscitative endovascular balloon occlusion of the aorta for prolonged hemorrhage control in a highly lethal porcine injury model. J Trauma Acute Care Surg. 2020;88(2):298-304.
Ectonucleotidases in Ischemia Reperfusion Injury: Unravelling the Interplay With Mitochondrial Dysfunction in Liver Transplantation. Transplant Proc. 2024;56(7):1598-1606.
Mentorship and Training
Dr. Hoareau mentors trainees around all aspects of translational acute care research with a strong interest and commitment to diversity, equity, and inclusion. He is part of several pipelines for trainees from underrepresented minorities.
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Faculty
Guillaume Hoareau, DVM, PhD
Associate Professor of Emergency Medicine